![]() The results of the computational structure predictions will be presented and discussed. We applied this method (on common desktop hardware) to the Second Antibody Modeling Assessment (AMA-II) target structures as well as an experimental specialized CDR-H3 loop modeling method. In this work, we present a method for automatic modeling of the FV region of an immunoglobulin based upon the use of a precompiled antibody x-ray structure database, which serves as a source of framework and hypervariable region structural templates that are grafted together. ![]() Accurate computational modeling of isolated protein loop regions can be quite difficult consequently, modeling an antigen binding site that includes six loops is particularly challenging. ![]() The success of antibody-based drugs has led to an increased demand for predictive computational tools to assist antibody engineering efforts surrounding the six hypervariable loop regions making up the antigen binding site. ![]() Assessment of fully automated antibody homology modeling protocols in molecular operating environmentĬhemical Computing Group, Inc., Montreal, Quebec, H3A 2R7, Canada ![]()
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